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KMID : 0363620070280020137
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Journal of Korean Oriental Medicine
2007 Volume.28 No. 2 p.137 ~ p.154
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The Effects of Gagbungyunsoo-tanghap Zeungsonbakchul-san (GYZB) Hot Water Extract & Ultra-fine Powder on the Alzheimer’s Disease Model
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Choi Bo-Yun
Lee Sang-Ryong
Jung In-Chul
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Abstract
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Objective : This experiment was designed to investigate the effect of the GYZB hot water extract & ultra-fine powder on the Alzheimer’s disease model induced by amyloid {beta} protein ({beta}A).
Methods : We measured the effects of the GYZB hot water extract on expression of IL-1{beta}, IL-6 mRNA and production of IL-6, TNF-{alpha} in the BV2 microglial cell line treated with lipopolysaccharide (LPS). The effects of the GYZB hot water extract & ultra-fine powder on (1) the behavior, (2) expression of IL-1{beta} and TNF-{alpha}, (3) glucose in serum, (4) the infarction area of the hippocampus, and brain tissue injury in mice induced with Alzheimer’s diseased by {beta}A were investigated.
Results : The GYZB hot water extract suppressed the expression of IL-1{beta} and IL-6 mRNA and significantly suppressed the production of IL-6 and TNF-{alpha} in the BV2 microglial cell line treated with LPS. The GYZB hot water extract & ultra-fine powder showed a significant inhibitory effect on the memory deficit of the mice with Alzheimer’s disease induced by {beta}A in the Morris water maze experiment, which measured stop-through latency and distance movement-through latency. The GYZB ultra-fine powder significantly suppressed the expression of IL-1{beta} and TNF-{alpha} protein, and the GYZB hot water extract significantly suppressed the expression of TNF-{alpha} protein in the microglial cell of mice with Alzheimer’s disease induced by {beta}A. The GYZB hot water extract & ultra-fine powder reduced the infarction area of hippocampus in the mice with Alzheimer’s disease induced by {beta}A.
Conclusion : These results suggest that GYZB hot water extract & ultra-fine powder may be effective for the prevention and treatment of Alzheimer’s disease. Investigation into the clinical use of GYZB for Alzheimer’s disease is suggested for future research.
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KEYWORD
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Alzheimer’s disease, Gagbungyunsoo-tanghap Zeungsonbakchul-san (GYZB), hot water extract, ultra-fine powder
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